We therefore investigated the effects of TNFAIP3 expression in IEC on immune homeostasis in the intestines of immune-compromised mice. Intestinal epithelial cell (IEC) expression of TNFAIP3 improves barrier function and tight junction integrity and prevents dextran sulfate sodium (DSS)-induced IEC death and colitis. TNFAIP3 also protects against TNF-induced cell death. ![]() Tumor necrosis factor-induced protein 3 (TNFAIP3 also known as A20) negatively regulates NF-κB and MAPK signals to control inflammatory responses.
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